ethyl 2-methylpyrazole-3-carboxylate
1-甲基-1H-吡唑-5-甲酸乙酯
CAS: 197079-26-8
Molecular Formula: C7H10N2O2
ethyl 2-methylpyrazole-3-carboxylate - Names and Identifiers
ethyl 2-methylpyrazole-3-carboxylate - Physico-chemical Properties
| Molecular Formula | C7H10N2O2 |
| Molar Mass | 154.17 |
| Density | 1.14±0.1 g/cm3 (20 ºC 760 Torr) |
| Boling Point | 238.5±13.0℃ (760 Torr) |
| Flash Point | 98.1±19.8℃ |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | n20/D1.483 |
ethyl 2-methylpyrazole-3-carboxylate - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| UN IDs | NA 1993 / PGIII |
| WGK Germany | 3 |
| HS Code | 29339900 |
ethyl 2-methylpyrazole-3-carboxylate - Introduction
Ethyl 1-methyl-1H-pyrazole-5-carboxylate, also known as Methylpyrazole-5-carboxylate, is an organic compound. Its molecular formula is C7H8N2O2 and its structural formula is CH3C6H4N2O2.
Nature:
1-Methyl-1H-pyrazole-5-carboxylic acid ethyl ester is a colorless to light yellow liquid with a special aromatic odor. It has good solubility and is easily soluble in ethanol and ether.
Use:
1-Methyl-1H-pyrazole-5-carboxylic acid ethyl ester is commonly used as an intermediate in pharmaceutical synthesis. It can be used to synthesize a variety of drugs and drug precursors, such as antidepressant, anti-anxiety, anti-tremor and other drugs. In addition, it can also be used as an important raw material in the synthesis of pesticides.
Preparation Method:
There are many preparation methods of 1-methyl -1H-pyrazole-5-carboxylic acid ethyl ester, among which the more commonly used method is the reaction of pyrazole and methyl alkoxy ethyl formate under acidic conditions. The specific step is that pyrazole is added to methyl alkoxyformate ethyl ester, and the product is obtained by esterification reaction under the catalysis of an acidic catalyst.
Safety Information:
1-Methyl-1H-pyrazole-5-carboxylic acid ethyl ester has low toxicity, but it is still necessary to pay attention to safe operation. It is a flammable liquid, and it is easy to burn and explode when encountering open flames or high temperatures, and needs to be kept away from fire sources. Wear protective gloves, glasses and other personal protective equipment during operation to avoid contact with skin and eyes. At the same time, waste items should be properly preserved and disposed of, and attention should be paid to environmental protection.
Nature:
1-Methyl-1H-pyrazole-5-carboxylic acid ethyl ester is a colorless to light yellow liquid with a special aromatic odor. It has good solubility and is easily soluble in ethanol and ether.
Use:
1-Methyl-1H-pyrazole-5-carboxylic acid ethyl ester is commonly used as an intermediate in pharmaceutical synthesis. It can be used to synthesize a variety of drugs and drug precursors, such as antidepressant, anti-anxiety, anti-tremor and other drugs. In addition, it can also be used as an important raw material in the synthesis of pesticides.
Preparation Method:
There are many preparation methods of 1-methyl -1H-pyrazole-5-carboxylic acid ethyl ester, among which the more commonly used method is the reaction of pyrazole and methyl alkoxy ethyl formate under acidic conditions. The specific step is that pyrazole is added to methyl alkoxyformate ethyl ester, and the product is obtained by esterification reaction under the catalysis of an acidic catalyst.
Safety Information:
1-Methyl-1H-pyrazole-5-carboxylic acid ethyl ester has low toxicity, but it is still necessary to pay attention to safe operation. It is a flammable liquid, and it is easy to burn and explode when encountering open flames or high temperatures, and needs to be kept away from fire sources. Wear protective gloves, glasses and other personal protective equipment during operation to avoid contact with skin and eyes. At the same time, waste items should be properly preserved and disposed of, and attention should be paid to environmental protection.
Last Update：2024-04-09 21:11:58
